By Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)
The ebook includes unique articles and studies awarded on the sixth overseas iciness convention on Neurodegeneration, held from November 20–23, 1997 in Kitzbuhel/Austria. the purpose of this convention used to be to give and talk about contemporary information at the interface among neuroimmunology and neurodegeneration, particularly susceptibility to autoimmune and neurodegenerative techniques, neuroprotection and restorative therapy innovations. those matters have been mentioned within the gentle of modern advancements in a number of sclerosis, Parkinson’s affliction, amyotrophic lateral sclerosis, Huntington’s sickness and multisystem atrophy. The articles spotlight subject matters, that are quite fascinating for the clinician and the neuroscientist. a few of the neuroprotective options have already been constructed or are at the moment clinically investigated. The neuroprotective function of deep mind stimulation, antiglutamatergic remedy and apomorphine should be tested in scientific reviews within the close to destiny. this can be additionally the case for destiny healing techniques to recovery of the broken fearful approach, akin to somatic gene treatment, implantation of genetically transformed cell-lines and medically managed and directed improvement of embryonic cells. The convention highlighted the function of the glia, which turns out to play a key function, either in regularly as neuroimmunological and neurodegenerative problems categorised ailments, as indicated above. the themes mentioned within the booklet are major for fresh advancements in medical neurology and neuroscience, as proven within the present literature and at foreign congresses.
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Extra info for Advances in Research on Neurodegeneration: Volume 6
Rascol proportion of early patients with Parkinson's disease than what is still too often claimed by some opinion leaders can be adequately manadged during several years with an agonist alone. To our best knowledge, none of the "newer" dopamine agonist has ever been compared to selegiline, L-dopa slow release formulations or COMT inhibitors in "de novo" patients. Conclusion In summary, pramipexole and ropinirole are 2 drugs which look very much the same. They are both selective D2 (D3) agonists with an intermediate elimination half-life of few hours, definitely longer than that of levodopa.
Lancet 2: 1355-1356 Chase TN (1998) The significance of continuous dopaminergic stimulation in the treatment of Parkinson's disease. Drug 55: S1-S9 Cummings JL (1992) Depression and Parkinson's disease: a review. Am J Psychiatry 149: 443-454 Factor SA, Weiner WJ (1993) Early combination therapy with bromocriptine and levodopa in Parkinson's disease. Mov Disord 3: 257-262 Fariello RG (1998) Pharmacodynamic and pharmacokinetic features of Cabergoline. Rationale for use in Parkinson's disease. Drugs 55: S10-S16 Felton DL, Felton SY, Fuller RW, Romano TD, Smalstig EB, Wong DT, Clemess JA (1992) Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged Fischer-344 rats.
However, all of them have specific characteristics, which provide some differences from one drug to the other. , 1993; Uitti and Ahlskog, 1996). These differences are often put forward for marketing purposes, to try to establish that these compounds are not "metoo" drugs. However, the results of the controlled comparative clinical trials, when available, are far less demonstrative and do not often convince that any agonist is indeed truely superior to the others. Which agonist to prefer, and when to use it to treat optimally our patients with Parkinson's disease are thus two distinct questions which both remain unslolved at the present time, because we still lack, in 1998, objective, reliable and convincing demonstrative comparative data.
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